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Friday, July 24, 2020 | History

3 edition of Bioassay of p-chloroaniline for possible carcinogenicity found in the catalog.

Bioassay of p-chloroaniline for possible carcinogenicity

by National Cancer Institute (U.S.). Division of Cancer Cause and Prevention.

  • 318 Want to read
  • 14 Currently reading

Published by Dept. of Health, Education, and Welfare, Public Health Service, National Institutes of Health in Bethesda, Md .
Written in English

    Subjects:
  • Carcinogens.,
  • Dyes and dyeing -- Toxicology.

  • Edition Notes

    StatementCarcinogenesis Testing Program, Division of Cancer Cause and Prevention, National Cancer Institute, National Institutes of Health.
    SeriesDHEW publication -- no. (NIH) 79-1475, Carcinogenesis technical report series -- no. 189
    ContributionsNational Institutes of Health (U.S.)
    The Physical Object
    Pagination90 p. in various pagings :
    Number of Pages90
    ID Numbers
    Open LibraryOL22412410M

    Bioassay of p-chloroaniline for possible carcinogenicity Bethesda (MD): United States Department of Health and Human Services, Public Health Service Jan Abstract. Carcinogen bioassay involves exposure of laboratory animals to one or more levels of the test substance, with tumor occurrence rates in the treated groups evaluated relative to those in unexposed controls (Bickis and Krewski, a).

      BIOASSAY OF ANTHRANILIC ACID FOR POSSIBLE CARCINOGENICITY CAS NO. [National Cancer Institute] on *FREE* shipping on qualifying offers. US Department of Health National Cancer Institute Carcinogenesis Technical Report no. 4to wraps. 92p. Light depository library markings. VG. p-Chloroaniline Pharmaceutical Secondary Standard; Certified Reference Material Synonym: 4-Chloroaniline CAS Number Linear Formula ClC 6 H 4 NH 2. Molecular Weight Beilstein/REAXYS Number EC Number MDL number MFCD PubChem Substance ID NACRES NA

    |a Bioassay of sulfisoxazole for possible carcinogenicity |h [electronic resource] / |c Carcinogenesis Testing Program, Division of Cancer Cause and Prevention, National Cancer Institute, National Institutes of . al Toxicology Program. Bioassay of Chlorobenzilate for Possible Carcinogenicity (CAS No. ). TR No U.S. Department of Health and Human Services, Public Health Service, National Institutes of Health, Bethesda, MD.


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Bioassay of p-chloroaniline for possible carcinogenicity by National Cancer Institute (U.S.). Division of Cancer Cause and Prevention. Download PDF EPUB FB2

SUMMARY A bioassay for the possible carcinogen1c1ty of p-chloroaniline was conducted using Fischer rats and B6C3Fl mice. p-Chloroani­ line was administered in the feed, at either of two concentrations, to groups of 50 male and 50 female animals of each species. Get this from a library. Bioassay of p-chloroaniline for possible carcinogenicity.

[Litton-Bionetics, inc.; National Institutes of Health (U.S.); Carcinogenesis Testing Program (U.S.)]. A bioassay for the possible carcinogenicity of p-chloroaniline was conducted using Fisher rats and B6C3F1 mice. p-Chloroaniline was administered in the feed, at either of two concentrations, to groups of 50 male and 50 female animals of each species.

Twenty animals of. Bioassay of p-Chloroaniline for Possible Carcinogenicity (CASRN ) Chemical (Study Title) CASRN Peer Review Date Route/Exposure Levels Study Laboratory; p-Chloroaniline 10/25/ Dosed-Feed R: 0, M: 0, PPM/50 PER GROUP: Litton Bionetics, Inc.

Levels of Evidence. NCI (National Cancer Institute). Bioassay of p-chloroaniline for possible carcinogenicity. NCI Carcinogenesis Tech. Rep. Ser. NTIS PB Groups of 20 and 50 F rats of each sex were exposed to p-chloroaniline in the diet at concentration of 0, or ppm for 78 weeks followed by an observation period of 24 weeks.

p-Chloroaniline (PCA), a dye intermediate, was evaluated for potential long-term toxicity and of 50 F/N rats of each sex were given by gavage PCA hydrochloride in deionized water at doses of 0, 2, 6 or 18 mg/kg body weight, 5 days/wk for wk.

Groups of 50 male and female B6C3F 1 mice of each sex were given 0, 3, 10 or 30 mg/kg on the same schedule. Bioassay of p-Chloroaniline for Possible Carcinogenicity (CAS No. National Toxicology Program. Natl Toxicol Program Tech Rep Ser,01 Jan Cited by: 0.

tion are provided in CICADs, whenever possible. These examples cannot be considered as representing all possible exposure situations, but are provided as guidance only.

The reader is referred to EHC While every effort is made to ensure that CICADs represent the current status of knowledge, new informa-tion is being developed constantly. No Significant Risk Levels for p-Chloroaniline and p-Chloroaniline Hydrochloride Public notices related to this chemical: Notice of Proposed Rulemaking Ti California Code of Regulations Amendment to Section Specific Regulatory Levels Posing No Significant Risk: p-chloroaniline and p-chloroaniline hydrochloride.

In male /Fischer / rats administered (14)C-labelled compound (5 mCi/mmol ( mCi/mg) (radiochemical purity unspecified)) at mg/kg bw by gavage in N hydrochloric acid, % of the dose was excreted in urine and % in feces by 24 hr; only 4% was excreted as unchanged amine in urine, % in bile and 1% in seven days, appreciable radiolabel was still present in.

A bioassay of p-cresidine for possible carcinogenicity was conducted using Fischer rats and B6C3F1 mice. p-Cresidine was administered in the feed, at either of two concentrations, to groups of 50 male and 50 female animals of each species.

The dietary concentrations used. The item Bioassay of chlordane for possible carcinogenicity, [prepared at Tracor Jitco, inc.] represents a specific, individual, material embodiment of a distinct intellectual or artistic creation found in Indiana State Library.

This item is available to borrow from 1 library branch. P-chloroaniline was selected by the National Cancer Institute for bioassay because of the high incidence of bladder cancer observed among those who worked with it.

Studies strongly suggest carcinogenicity in rats and mice (NTIS website). There are established recommended minimum allowances by the EU's Pharmacopoe   Journals & Books; Help Download full Fischer rats and C57BL/6 x C3H F, mice Cancer National Cancer Institute () Bioassay of Dapsone for Possible Carcinogenicity Tech Rep Ser No 20 U S Govt Print Off, Washington, DC National Cancer Institute () Bioassay of Aniline Hydroxychlonde for Possible Carcinogenicity Tech Rep.

It may be possible to analyze other compounds at the same time. Interferences may be avoided by proper selection of column and parameters.

Disadvantages Silica gel tubes adsorb water vapor from, the air, thereby possibly lowering the capacity of the tube for p-chloroaniline. This criterion is based on carcinogenicity of risk. Alternate risk levels may be obtained by moving the decimal point (e.g., for a risk level ofmove the decimal point in the recommended criterion one place to the right).

Benzo(a)pyrene (P) This criterion is based on carcinogenicity of risk. A bioassay of 3,3'-iminobispropanol dimethanesulfonate (ester) hydrochloride [IPD] for possible carcinogenicity was conducted by administering the test chemical intraperitoneally to Sprague-Dawley rats and B6C3F1 mice.

The IPD was injected three times per week to groups of 35 animals, using doses of 12, 24, or 48 mg/kg for the rats, and 20 or 40 mg/kg for the mice. Carcinogenesis bioassay of trichloroethylene: CAS No. by United States. National Cancer Institute.

Carcinogen Bioassay and Program Resources Branch; U.S. Dept. of Health, Education, and Welfare, Public Health Service. National Institutes of Health. View Lancet Oncology summary as HTML or PDF French version of the Lancet Oncology summary (hosted by Centre Léon Bérard) ***This book was highly commended in the Public Health category of the British Medical Association's annual Medical Book Competition.***.

NTP. TR p-Chloroaniline (). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP). Accessed h. F rats fed diets containing aniline hydrochloride, p-chloroaniline, azobenzene, o-toluidine hydrochloride, 4,4' -sulfonyldianiline, or D & C red No.

9. J Natl Cancer Inst 73(1) Griciute L, Tomatis L (). Carcinogenicity of dapsone in mice and rats. Int J Cancer Bioassay of p- chloroaniline for possible carcinogenicity.

NCI Carcinogenesis Tech. Rep. Ser. No. NTIS PB Method(s): Groups of 20 and 50 F rats of each sex were exposed to p- chloroaniline in the diet at concentration of 0, or ppm for 78 weeks followed by an observation period of 24 weeks.4-Chloroaniline is an organochlorine compound with the formula ClC 6 H 4 NH pale yellow solid is one of the three isomers of chloroaniline.

Preparation. 4-Chloroaniline is not prepared from aniline, which tends to overchlorinate.